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KMID : 0043320010240060597
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Archives of Pharmacal Research
2001 Volume.24 No. 6 p.597 ~ p.600
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Induction of Quinone Reductase Activity by Stilbene Analogs in Mouse Hepa 1c1c7 Cells
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Heo YH
Kim SH/Park JE/Jeong LS/Lee SK
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Abstract
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Based on the potential cancer chemopreventive activity of resveratrol, a trihydroxystilbene with the induction of quinone reductase activityl this study was designed to determin e if stilbene-related compounds were inducers of phase II detoxifying metabolic enzyme quinone reductase (QR) in the mouse hepatoma Hepa 1clc7 cells. Among the thirteen compounds tested, several compounds including 3,4,5,3’,5’- pentamethoxy-tranf-stilbene were found to potentially induce QR activity in this cell line. In addition substitution with 3-thiofurane ring instead of phenyl ring in the stilbene skeleton also exhibited potential induction of QR activity. This result will give primary information to design the potential inducers of QR activity in the stilbene analogs.
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KEYWORD
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